Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. [electronic resource]
- Biochimica et biophysica acta May 2015
- 605-19 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
0006-3002
10.1016/j.bbalip.2015.01.007 doi
Animals Biological Transport Biotransformation Cell Death Cell Line Cholesterol, HDL--metabolism Chromatography, High Pressure Liquid Enzyme Inhibitors--pharmacology Esterification Fatty Acids--metabolism Group IV Phospholipases A2--antagonists & inhibitors Humans Ketocholesterols--metabolism Macaca mulatta Male Mass Spectrometry RNA Interference Retinal Pigment Epithelium--drug effects Sterol O-Acyltransferase--antagonists & inhibitors Time Factors Transfection