Sagawa, Morihiko <br/><br/>
TM-233, a novel analog of 1'-acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities.  [electronic resource] 

 -  Cancer science  Apr 2015 
 - 438-46 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1349-7006 
<br/><br/><label>Standard No.: </label>10.1111/cas.12616  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Benzyl Alcohols--chemistry<br/>Boronic Acids--pharmacology<br/>Bortezomib<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Drug Resistance, Neoplasm--drug effects<br/>G1 Phase Cell Cycle Checkpoints--drug effects<br/>Humans<br/>Janus Kinase 2--antagonists & inhibitors<br/>Multiple Myeloma--enzymology<br/>Myeloid Cell Leukemia Sequence 1 Protein--biosynthesis<br/>NF-kappa B--antagonists & inhibitors<br/>Proteasome Endopeptidase Complex--metabolism<br/>Proteasome Inhibitors--pharmacology<br/>Proto-Oncogene Proteins c-bcl-2--biosynthesis<br/>Pyrazines--pharmacology<br/>Quantitative Structure-Activity Relationship<br/>STAT3 Transcription Factor--antagonists & inhibitors<br/>bcl-X Protein--biosynthesis