TY  - GEN
AU  - May,Patrick C
AU  - Willis,Brian A
AU  - Lowe,Stephen L
AU  - Dean,Robert A
AU  - Monk,Scott A
AU  - Cocke,Patrick J
AU  - Audia,James E
AU  - Boggs,Leonard N
AU  - Borders,Anthony R
AU  - Brier,Richard A
AU  - Calligaro,David O
AU  - Day,Theresa A
AU  - Ereshefsky,Larry
AU  - Erickson,Jon A
AU  - Gevorkyan,Hykop
AU  - Gonzales,Celedon R
AU  - James,Douglas E
AU  - Jhee,Stanford S
AU  - Komjathy,Steven F
AU  - Li,Linglin
AU  - Lindstrom,Terry D
AU  - Mathes,Brian M
AU  - Martényi,Ferenc
AU  - Sheehan,Scott M
AU  - Stout,Stephanie L
AU  - Timm,David E
AU  - Vaught,Grant M
AU  - Watson,Brian M
AU  - Winneroski,Leonard L
AU  - Yang,Zhixiang
AU  - Mergott,Dustin J
TI  - The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans
SN  - 1529-2401
PY  - 2015///0324
KW  - Alzheimer Disease
KW  - drug therapy
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Amyloid beta-Peptides
KW  - blood
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Disease Models, Animal
KW  - Dogs
KW  - Heterocyclic Compounds, 2-Ring
KW  - pharmacokinetics
KW  - Humans
KW  - Mice
KW  - Picolinic Acids
KW  - Protease Inhibitors
N1  - Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1523/JNEUROSCI.4129-14.2015
ER  -