Vosper, Jonathan <br/><br/>
Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation.  [electronic resource] 

 -  Oncotarget  Feb 2015 
 - 2889-902 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1949-2553 
<br/><br/><label>Standard No.: </label>10.18632/oncotarget.3068  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alkyl and Aryl Transferases--antagonists & inhibitors<br/>Animals<br/>Antigens, CD<br/>Antineoplastic Agents--pharmacology<br/>Cadherins--genetics<br/>Cdh1 Proteins--genetics<br/>Cell Proliferation--drug effects<br/>Cyclin-Dependent Kinase Inhibitor p21--metabolism<br/>Cyclin-Dependent Kinase Inhibitor p27--metabolism<br/>Down-Regulation<br/>Genes, APC<br/>HeLa Cells<br/>Humans<br/>Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology<br/>Lovastatin--pharmacology<br/>Mice<br/>NIH 3T3 Cells<br/>Neoplasms--drug therapy<br/>Polyisoprenyl Phosphates--metabolism<br/>Proteasome Endopeptidase Complex--metabolism<br/>Proteolysis<br/>S-Phase Kinase-Associated Proteins--genetics<br/>Signal Transduction--drug effects<br/>Time Factors<br/>Transfection<br/>U937 Cells