TY  - GEN
AU  - Jayaraman,Ramesh
AU  - Pasha,Mohammed Khalid
AU  - Williams,Anthony
AU  - Goh,Kee Cee
AU  - Ethirajulu,Kantharaj
TI  - Metabolism and Disposition of Pacritinib (SB1518), an Orally Active Janus Kinase 2 Inhibitor in Preclinical Species and Humans
SN  - 1874-0758
PY  - 2016///0401
KW  - Administration, Oral
KW  - Animals
KW  - Biological Availability
KW  - Biotransformation
KW  - Bridged-Ring Compounds
KW  - administration & dosage
KW  - Cells, Cultured
KW  - Cytochrome P-450 CYP3A
KW  - metabolism
KW  - Dealkylation
KW  - Dogs
KW  - Feces
KW  - chemistry
KW  - Hepatobiliary Elimination
KW  - Hepatocytes
KW  - Humans
KW  - Janus Kinase 2
KW  - antagonists & inhibitors
KW  - Liver
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Mice, Inbred BALB C
KW  - Mice, Nude
KW  - Microsomes, Liver
KW  - Models, Biological
KW  - Oxidation-Reduction
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Pyrimidines
KW  - Rats
KW  - Rats, Wistar
KW  - Species Specificity
KW  - Tissue Distribution
N1  - Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article
UR  - https://doi.org/10.2174/1872312809666150119105250
ER  -