TY  - GEN
AU  - Park,Jin-Hee
AU  - Lee,Ga-Eun
AU  - Lee,So-Deok
AU  - Hien,Tran Thi
AU  - Kim,Sujin
AU  - Yang,Jin Won
AU  - Cho,Joong-Heui
AU  - Ko,Hyojin
AU  - Lim,Sung-Chul
AU  - Kim,Yoon-Gyoon
AU  - Kang,Keon-Wook
AU  - Kim,Yong-Chul
TI  - Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62
SN  - 1520-4804
PY  - 2015///0615
KW  - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
KW  - analogs & derivatives
KW  - Animals
KW  - Arthritis, Experimental
KW  - chemically induced
KW  - Carrageenan
KW  - toxicity
KW  - Cattle
KW  - Collagen Type II
KW  - Drug Discovery
KW  - Edema
KW  - Enzyme-Linked Immunosorbent Assay
KW  - HEK293 Cells
KW  - Humans
KW  - Hydantoins
KW  - chemistry
KW  - Immunoblotting
KW  - Inflammation
KW  - Interleukin-1beta
KW  - metabolism
KW  - Long-Term Potentiation
KW  - Macrophages
KW  - cytology
KW  - Male
KW  - Mice, Inbred DBA
KW  - Molecular Structure
KW  - Monocytes
KW  - Neuralgia
KW  - drug therapy
KW  - Purinergic P2X Receptor Antagonists
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Purinergic P2X7
KW  - Structure-Activity Relationship
KW  - Sulfonic Acids
KW  - Tissue Distribution
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm500324g
ER  -