Park, Jin-Hee <br/><br/>
Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62.  [electronic resource] 

 -  Journal of medicinal chemistry  Mar 2015 
 - 2114-34 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm500324g  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine--analogs & derivatives<br/>Animals<br/>Arthritis, Experimental--chemically induced<br/>Carrageenan--toxicity<br/>Cattle<br/>Collagen Type II--toxicity<br/>Drug Discovery<br/>Edema--chemically induced<br/>Enzyme-Linked Immunosorbent Assay<br/>HEK293 Cells<br/>Humans<br/>Hydantoins--chemistry<br/>Immunoblotting<br/>Inflammation--chemically induced<br/>Interleukin-1beta--metabolism<br/>Long-Term Potentiation<br/>Macrophages--cytology<br/>Male<br/>Mice, Inbred DBA<br/>Molecular Structure<br/>Monocytes--cytology<br/>Neuralgia--drug therapy<br/>Purinergic P2X Receptor Antagonists--chemistry<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptors, Purinergic P2X7--chemistry<br/>Structure-Activity Relationship<br/>Sulfonic Acids--chemistry<br/>Tissue Distribution