Frankowski, Kevin J <br/><br/>
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.  [electronic resource] 

 -  Bioorganic & medicinal chemistry  Jul 2015 
 - 3948-56 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>1464-3391 
<br/><br/><label>Standard No.: </label>10.1016/j.bmc.2014.12.033  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Arrestins--metabolism<br/>Benzamides--chemistry<br/>CHO Cells<br/>Chemistry Techniques, Synthetic<br/>Cricetulus<br/>Drug Evaluation, Preclinical--methods<br/>Guanosine 5'-O-(3-Thiotriphosphate)--metabolism<br/>Humans<br/>Naltrexone--analogs & derivatives<br/>Narcotic Antagonists--chemistry<br/>Receptors, Opioid, kappa--antagonists & inhibitors<br/>Structure-Activity Relationship<br/>Sulfonamides--chemistry<br/>Tetrahydroisoquinolines--chemistry<br/>beta-Arrestins