Na, Tae-Young

22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. [electronic resource] - The Journal of pathology Apr 2015 - 710-20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-9896

10.1002/path.4494 doi


Animals
Autocrine Communication--drug effects
Binding Sites
Cell Hypoxia
Cells, Cultured
Chemokine CCL2--genetics
Cytoprotection
Disease Models, Animal
Ethanol
Fatty Liver, Alcoholic--metabolism
Hepatocytes--drug effects
Hydroxycholesterols--pharmacology
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Kupffer Cells--drug effects
Lipogenesis--drug effects
Liver--drug effects
Liver X Receptors
Male
Mice, Inbred C57BL
Orphan Nuclear Receptors--antagonists & inhibitors
Paracrine Communication--drug effects
Promoter Regions, Genetic
Signal Transduction--drug effects
Transfection
Up-Regulation