Chen, Zhen

Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. [electronic resource] - Circulation Mar 2015 - 805-14 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1524-4539

10.1161/CIRCULATIONAHA.114.013675 doi


Aged
Angiotensin II--toxicity
Animals
Coronary Disease--blood
Endothelial Cells--metabolism
Endothelium, Vascular--metabolism
Female
Free Radical Scavengers--pharmacology
Gene Expression Regulation
Genes, Reporter
HEK293 Cells
Human Umbilical Vein Endothelial Cells
Humans
Hydrogen Peroxide--toxicity
Hypercholesterolemia--genetics
Immunity, Innate--genetics
Inflammasomes--metabolism
Interleukin-1beta--blood
Kruppel-Like Factor 4
Lipoproteins, LDL--toxicity
Male
Mice
Mice, Transgenic
MicroRNAs--biosynthesis
Middle Aged
Organometallic Compounds--pharmacology
Oxidative Stress--genetics
Recombinant Fusion Proteins--metabolism
Salicylates--pharmacology
Sterol Regulatory Element Binding Protein 2--genetics
Transcriptional Activation
Zebrafish
Zebrafish Proteins--physiology