TY - GEN AU - Seizer,Peter AU - Ungern-Sternberg,Saskia N I V AU - Schönberger,Tanja AU - Borst,Oliver AU - Münzer,Patrick AU - Schmidt,Eva-Maria AU - Mack,Andreas F AU - Heinzmann,David AU - Chatterjee,Madhumita AU - Langer,Harald AU - Malešević,Miroslav AU - Lang,Florian AU - Gawaz,Meinrad AU - Fischer,Gunter AU - May,Andreas E TI - Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo SN - 1524-4636 PY - 2016///0412 KW - Animals KW - Basigin KW - blood KW - Blood Platelets KW - drug effects KW - Carotid Artery Injuries KW - Cell Degranulation KW - Chlorides KW - Cyclophilin A KW - antagonists & inhibitors KW - Disease Models, Animal KW - Dose-Response Relationship, Drug KW - Ferric Compounds KW - Fibrinolytic Agents KW - pharmacology KW - Humans KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Phosphatidylinositol 3-Kinases KW - Platelet Adhesiveness KW - Platelet Aggregation KW - Platelet Aggregation Inhibitors KW - Proto-Oncogene Proteins c-akt KW - Signal Transduction KW - Thrombosis KW - Time Factors N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1161/ATVBAHA.114.305112 ER -