TY  - GEN
AU  - Alvarez-Calderon,Francesca
AU  - Gregory,Mark A
AU  - Pham-Danis,Catherine
AU  - DeRyckere,Deborah
AU  - Stevens,Brett M
AU  - Zaberezhnyy,Vadym
AU  - Hill,Amanda A
AU  - Gemta,Lelisa
AU  - Kumar,Amit
AU  - Kumar,Vijay
AU  - Wempe,Michael F
AU  - Pollyea,Daniel A
AU  - Jordan,Craig T
AU  - Serkova,Natalie J
AU  - Graham,Douglas K
AU  - DeGregori,James
TI  - Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations
SN  - 1557-3265
PY  - 2016///0204
KW  - Animals
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Dihydrolipoyllysine-Residue Acetyltransferase
KW  - genetics
KW  - Disease Models, Animal
KW  - Female
KW  - Fusion Proteins, bcr-abl
KW  - metabolism
KW  - Humans
KW  - Imatinib Mesylate
KW  - Ketone Oxidoreductases
KW  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KW  - drug therapy
KW  - Membrane Potential, Mitochondrial
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Inbred NOD
KW  - Mice, Knockout
KW  - Mitochondria
KW  - Mitochondrial Proteins
KW  - Mitochondrial Proton-Translocating ATPases
KW  - antagonists & inhibitors
KW  - Oligomycins
KW  - Protein Kinase Inhibitors
KW  - Protein-Tyrosine Kinases
KW  - RNA Interference
KW  - RNA, Small Interfering
KW  - Superoxides
KW  - fms-Like Tyrosine Kinase 3
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1078-0432.CCR-14-2146
ER  -