TY  - GEN
AU  - Sajish,Mathew
AU  - Schimmel,Paul
TI  - A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol
SN  - 1476-4687
PY  - 2015///0407
KW  - Alternative Splicing
KW  - Animals
KW  - Biocatalysis
KW  - drug effects
KW  - Catalytic Domain
KW  - Cell Nucleus
KW  - enzymology
KW  - Crystallography, X-Ray
KW  - Culture Media, Serum-Free
KW  - Enzyme Activation
KW  - Humans
KW  - Male
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Models, Molecular
KW  - Poly (ADP-Ribose) Polymerase-1
KW  - Poly Adenosine Diphosphate Ribose
KW  - metabolism
KW  - Poly(ADP-ribose) Polymerases
KW  - chemistry
KW  - Protein Conformation
KW  - Resveratrol
KW  - Signal Transduction
KW  - Sirtuin 1
KW  - Sirtuins
KW  - Stilbenes
KW  - antagonists & inhibitors
KW  - Tyrosine-tRNA Ligase
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature14028
ER  -