Li, Ao

The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway. [electronic resource] - European journal of pharmacology Jan 2015 - 71-87 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0712

10.1016/j.ejphar.2014.11.040 doi


14-3-3 Proteins--metabolism
Active Transport, Cell Nucleus--drug effects
Becaplermin
Cell Line
Cell Nucleus--drug effects
Cell Proliferation--drug effects
Cyclin D1--metabolism
Cyclin-Dependent Kinase 4--metabolism
Cyclin-Dependent Kinase 6--metabolism
Cyclin-Dependent Kinase Inhibitor p27--metabolism
Down-Regulation--drug effects
Forkhead Box Protein O3
Forkhead Transcription Factors--deficiency
Furans--pharmacology
G1 Phase Cell Cycle Checkpoints--drug effects
Gene Expression Regulation, Enzymologic--drug effects
Gene Knockdown Techniques
Hepatic Stellate Cells--cytology
Humans
Lignans--pharmacology
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation--drug effects
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-sis--pharmacology
RNA, Small Interfering--genetics
Resting Phase, Cell Cycle--drug effects
Signal Transduction--drug effects