TY - GEN AU - Yang,Sijun AU - Xia,Chunxiang AU - Li,Shali AU - Du,Leilei AU - Zhang,Lu AU - Zhou,Ronbin TI - Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity SN - 2213-2317 PY - 2015///0805 KW - Animals KW - Calcium KW - metabolism KW - Carrier Proteins KW - Gene Expression KW - Gene Knockdown Techniques KW - Glucose KW - Insulin KW - Insulin Secretion KW - Islets of Langerhans KW - drug effects KW - Kinesins KW - Lipopolysaccharides KW - pharmacology KW - Mitochondria KW - Mitochondrial Membranes KW - Mitophagy KW - Monomeric GTP-Binding Proteins KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - Neuropeptides KW - Palmitates KW - Protein Transport KW - Proteolysis KW - Ras Homolog Enriched in Brain Protein KW - Rats KW - Reactive Oxygen Species KW - Receptors, Cytoplasmic and Nuclear KW - genetics N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.redox.2014.04.001 ER -