Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. [electronic resource]
- Redox biology 2014
- 63-71 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2213-2317
10.1016/j.redox.2014.04.001 doi
Animals Calcium--metabolism Carrier Proteins Gene Expression Gene Knockdown Techniques Glucose--metabolism Insulin--metabolism Insulin Secretion Islets of Langerhans--drug effects Kinesins--metabolism Lipopolysaccharides--pharmacology Mitochondria--drug effects Mitochondrial Membranes--metabolism Mitophagy--drug effects Monomeric GTP-Binding Proteins--metabolism NLR Family, Pyrin Domain-Containing 3 Protein Neuropeptides--metabolism Palmitates--pharmacology Protein Transport Proteolysis--drug effects Ras Homolog Enriched in Brain Protein Rats Reactive Oxygen Species--metabolism Receptors, Cytoplasmic and Nuclear--genetics