Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. [electronic resource]
- Oncotarget Dec 2014
- 11971-85 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1949-2553
10.18632/oncotarget.2647 doi
ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters--antagonists & inhibitors Afatinib Animals Antineoplastic Agents--pharmacology Blotting, Western Cell Line, Tumor Drug Resistance, Multiple--drug effects Drug Resistance, Neoplasm--drug effects Female Flow Cytometry Humans Immunohistochemistry In Vitro Techniques Male Mice Mice, Inbred BALB C Neoplasm Proteins--antagonists & inhibitors Neoplasms, Experimental--drug therapy Quinazolines--pharmacology Real-Time Polymerase Chain Reaction Topotecan--pharmacology Xenograft Model Antitumor Assays