Wiegering, Armin <br/><br/>
E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.  [electronic resource] 

 -  Neoplasia (New York, N.Y.)  Nov 2014 
 - 972-81 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-5586 
<br/><br/><label>Standard No.: </label>10.1016/j.neo.2014.09.008  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Caco-2 Cells<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Cells, Cultured<br/>Colorectal Neoplasms--genetics<br/>Female<br/>Gene Expression--drug effects<br/>HCT116 Cells<br/>HT29 Cells<br/>Human Umbilical Vein Endothelial Cells--drug effects<br/>Humans<br/>Inhibitory Concentration 50<br/>Ki-67 Antigen--metabolism<br/>Mice, Inbred Strains<br/>Mice, Nude<br/>Mutation<br/>Neovascularization, Pathologic--prevention & control<br/>Phenylurea Compounds--pharmacology<br/>Protein Kinase Inhibitors--pharmacology<br/>Quinolines--pharmacology<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Treatment Outcome<br/>Xenograft Model Antitumor Assays--methods<br/>ras Proteins--genetics