TY  - GEN
AU  - Tan,Ying
AU  - Watkins,Amanda A
AU  - Freeman,Benjamin B
AU  - Meyers,John A
AU  - Rifkin,Ian R
AU  - Lerner,Adam
TI  - Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells
SN  - 1550-6606
PY  - 2016///0226
KW  - Active Transport, Cell Nucleus
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Apoptosis
KW  - drug effects
KW  - Base Sequence
KW  - Cell Proliferation
KW  - Cells, Cultured
KW  - Cyclic AMP
KW  - metabolism
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - Deoxyribonucleases
KW  - pharmacology
KW  - Female
KW  - Humans
KW  - Interferon Regulatory Factors
KW  - Interferon-alpha
KW  - biosynthesis
KW  - Interleukin-10
KW  - Interleukin-6
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - drug therapy
KW  - Lipopolysaccharide Receptors
KW  - Male
KW  - Middle Aged
KW  - Monocytes
KW  - immunology
KW  - Phosphodiesterase 4 Inhibitors
KW  - therapeutic use
KW  - Rolipram
KW  - Sequence Analysis, DNA
KW  - Signal Transduction
KW  - Toll-Like Receptor 7
KW  - antagonists & inhibitors
KW  - Toll-Like Receptor 8
KW  - Toll-Like Receptor 9
KW  - Transcription Factor RelA
KW  - Tumor Necrosis Factor-alpha
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.4049/jimmunol.1401854
ER  -