Tan, Ying <br/><br/>
Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells.  [electronic resource] 

 -  Journal of immunology (Baltimore, Md. : 1950)  Jan 2015 
 - 101-12 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1550-6606 
<br/><br/><label>Standard No.: </label>10.4049/jimmunol.1401854  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Active Transport, Cell Nucleus<br/>Adult<br/>Aged<br/>Aged, 80 and over<br/>Apoptosis--drug effects<br/>Base Sequence<br/>Cell Proliferation--drug effects<br/>Cells, Cultured<br/>Cyclic AMP--metabolism<br/>Cyclic Nucleotide Phosphodiesterases, Type 4--metabolism<br/>Deoxyribonucleases--pharmacology<br/>Female<br/>Humans<br/>Interferon Regulatory Factors--metabolism<br/>Interferon-alpha--biosynthesis<br/>Interleukin-10--biosynthesis<br/>Interleukin-6--biosynthesis<br/>Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy<br/>Lipopolysaccharide Receptors--metabolism<br/>Male<br/>Middle Aged<br/>Monocytes--immunology<br/>Phosphodiesterase 4 Inhibitors--therapeutic use<br/>Rolipram--pharmacology<br/>Sequence Analysis, DNA<br/>Signal Transduction<br/>Toll-Like Receptor 7--antagonists & inhibitors<br/>Toll-Like Receptor 8--antagonists & inhibitors<br/>Toll-Like Receptor 9--antagonists & inhibitors<br/>Transcription Factor RelA--antagonists & inhibitors<br/>Tumor Necrosis Factor-alpha--biosynthesis