Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. [electronic resource]
- Blood Jan 2015
- 619-28 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1528-0020
10.1182/blood-2014-08-594564 doi
Animals Blast Crisis--genetics Bone Marrow--enzymology Cell Differentiation Cell Line Cell Transformation, Neoplastic--genetics DNA (Cytosine-5-)-Methyltransferases DNA Methyltransferase 3A Hematopoiesis--genetics Hematopoietic Stem Cells--enzymology Leukemia, Myeloid, Acute--enzymology Mice Mice, Knockout Mutation Proto-Oncogene Proteins c-kit--genetics