TY  - GEN
AU  - Gurcha,Sudagar S
AU  - Usha,Veeraraghavan
AU  - Cox,Jonathan A G
AU  - Fütterer,Klaus
AU  - Abrahams,Katherine A
AU  - Bhatt,Apoorva
AU  - Alderwick,Luke J
AU  - Reynolds,Robert C
AU  - Loman,Nicholas J
AU  - Nataraj,VijayaShankar
AU  - Alemparte,Carlos
AU  - Barros,David
AU  - Lloyd,Adrian J
AU  - Ballell,Lluis
AU  - Hobrath,Judith V
AU  - Besra,Gurdyal S
TI  - Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target
SN  - 1932-6203
PY  - 2015///1222
KW  - Amino Acid Sequence
KW  - Antitubercular Agents
KW  - pharmacology
KW  - Aspartate-tRNA Ligase
KW  - chemistry
KW  - Cloning, Molecular
KW  - Crystallography, X-Ray
KW  - Dimerization
KW  - Drug Resistance, Multiple, Bacterial
KW  - drug effects
KW  - Humans
KW  - Microbial Sensitivity Tests
KW  - Molecular Sequence Data
KW  - Mycobacterium bovis
KW  - Mycobacterium smegmatis
KW  - Mycobacterium tuberculosis
KW  - Piperidines
KW  - Polymorphism, Single Nucleotide
KW  - Protein Binding
KW  - Recombinant Fusion Proteins
KW  - biosynthesis
KW  - Sequence Alignment
KW  - Sequence Analysis, DNA
KW  - Sequence Homology, Amino Acid
KW  - Thiazoles
KW  - Tuberculosis, Pulmonary
KW  - drug therapy
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0113568
ER  -