TY  - GEN
AU  - Seo,Jeong-Woo
AU  - Ma,Ming
AU  - Kwong,Thomas
AU  - Ju,Jianhua
AU  - Lim,Si-Kyu
AU  - Jiang,Hui
AU  - Lohman,Jeremy R
AU  - Yang,Chunying
AU  - Cleveland,John
AU  - Zazopoulos,Emmanuel
AU  - Farnet,Chris M
AU  - Shen,Ben
TI  - Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues
SN  - 1520-4995
PY  - 2015///0217
KW  - Antibiotics, Antineoplastic
KW  - biosynthesis
KW  - Bacterial Proteins
KW  - antagonists & inhibitors
KW  - Base Sequence
KW  - Bioreactors
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Drug Design
KW  - Gene Silencing
KW  - Humans
KW  - Macrolides
KW  - chemistry
KW  - Models, Biological
KW  - Molecular Sequence Data
KW  - Molecular Structure
KW  - Multigene Family
KW  - Mutant Proteins
KW  - Neoplasms
KW  - drug therapy
KW  - Piperidones
KW  - Polyketide Synthases
KW  - Polyketides
KW  - Protein Engineering
KW  - Recombinant Proteins
KW  - Stereoisomerism
KW  - Streptomyces
KW  - enzymology
KW  - Structure-Activity Relationship
N1  - Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/bi501396v
ER  -