Seo, Jeong-Woo <br/><br/>
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.  [electronic resource] 

 -  Biochemistry  Dec 2014 
 - 7854-65 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4995 
<br/><br/><label>Standard No.: </label>10.1021/bi501396v  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antibiotics, Antineoplastic--biosynthesis<br/>Bacterial Proteins--antagonists & inhibitors<br/>Base Sequence<br/>Bioreactors<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Drug Design<br/>Gene Silencing<br/>Humans<br/>Macrolides--chemistry<br/>Models, Biological<br/>Molecular Sequence Data<br/>Molecular Structure<br/>Multigene Family<br/>Mutant Proteins--chemistry<br/>Neoplasms--drug therapy<br/>Piperidones--chemistry<br/>Polyketide Synthases--antagonists & inhibitors<br/>Polyketides--chemistry<br/>Protein Engineering<br/>Recombinant Proteins--chemistry<br/>Stereoisomerism<br/>Streptomyces--enzymology<br/>Structure-Activity Relationship