Pasquier, Benoit <br/><br/>
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.  [electronic resource] 

 -  Journal of medicinal chemistry  Jan 2015 
 - 376-400 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm5013352  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Area Under Curve<br/>Bridged Bicyclo Compounds, Heterocyclic--chemistry<br/>Caco-2 Cells<br/>Cell Line, Tumor<br/>Class III Phosphatidylinositol 3-Kinases--antagonists & inhibitors<br/>Crystallography, X-Ray<br/>Drug Discovery<br/>Enzyme Inhibitors--chemistry<br/>HeLa Cells<br/>Humans<br/>Male<br/>Mice, SCID<br/>Models, Chemical<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Molecular Structure<br/>Neoplasms--drug therapy<br/>Protein Binding<br/>Protein Structure, Tertiary<br/>Pyrimidinones--chemistry<br/>Rats, Sprague-Dawley<br/>Sequence Homology, Amino Acid<br/>Thermodynamics<br/>Xenograft Model Antitumor Assays