Patton, John T

The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease. [electronic resource] - Oncotarget Feb 2015 - 2693-708 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1949-2553

10.18632/oncotarget.2098 doi


Adaptive Immunity--drug effects
Animals
Antineoplastic Agents--pharmacology
CD8-Positive T-Lymphocytes--drug effects
Cells, Cultured
Coculture Techniques
Cytotoxicity, Immunologic--drug effects
Epstein-Barr Virus Infections--drug therapy
Herpesvirus 4, Human--drug effects
Immunity, Innate--drug effects
Lymphocytes, Tumor-Infiltrating--drug effects
Lymphoproliferative Disorders--drug therapy
Mice, SCID
Protein Biosynthesis--drug effects
Proto-Oncogene Proteins c-akt--metabolism
STAT1 Transcription Factor--metabolism
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Time Factors
Triterpenes--pharmacology
Viral Matrix Proteins--metabolism