TY  - GEN
AU  - Thiel,Christoph
AU  - Schneckener,Sebastian
AU  - Krauss,Markus
AU  - Ghallab,Ahmed
AU  - Hofmann,Ute
AU  - Kanacher,Tobias
AU  - Zellmer,Sebastian
AU  - Gebhardt,Rolf
AU  - Hengstler,Jan G
AU  - Kuepfer,Lars
TI  - A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation
SN  - 1520-6017
PY  - 2015///0908
KW  - Animals
KW  - Cells, Cultured
KW  - Computational Biology
KW  - Cytochrome P-450 Enzyme System
KW  - genetics
KW  - Drug Evaluation, Preclinical
KW  - methods
KW  - Drugs, Investigational
KW  - metabolism
KW  - Gene Expression Profiling
KW  - Gene Expression Regulation
KW  - drug effects
KW  - Gene Expression Regulation, Enzymologic
KW  - Germany
KW  - Humans
KW  - Liver
KW  - cytology
KW  - Mice, Inbred C57BL
KW  - Models, Biological
KW  - Organ Specificity
KW  - Pharmacology, Clinical
KW  - Physiology, Comparative
KW  - Species Specificity
KW  - Specific Pathogen-Free Organisms
N1  - Publication Type: Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/jps.24214
ER  -