Thiel, Christoph <br/><br/>
A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.  [electronic resource] 

 -  Journal of pharmaceutical sciences  Jan 2015 
 - 191-206 p.  digital 
<br/><br/> Publication Type: Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-6017 
<br/><br/><label>Standard No.: </label>10.1002/jps.24214  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Cells, Cultured<br/>Computational Biology<br/>Cytochrome P-450 Enzyme System--genetics<br/>Drug Evaluation, Preclinical--methods<br/>Drugs, Investigational--metabolism<br/>Gene Expression Profiling<br/>Gene Expression Regulation--drug effects<br/>Gene Expression Regulation, Enzymologic--drug effects<br/>Germany<br/>Humans<br/>Liver--cytology<br/>Mice, Inbred C57BL<br/>Models, Biological<br/>Organ Specificity<br/>Pharmacology, Clinical--methods<br/>Physiology, Comparative--methods<br/>Species Specificity<br/>Specific Pathogen-Free Organisms