TY  - GEN
AU  - Deng,Gejing
AU  - Shen,Junqing
AU  - Yin,Ming
AU  - McManus,Jessica
AU  - Mathieu,Magali
AU  - Gee,Patricia
AU  - He,Timothy
AU  - Shi,Chaomei
AU  - Bedel,Olivier
AU  - McLean,Larry R
AU  - Le-Strat,Frank
AU  - Zhang,Ying
AU  - Marquette,Jean-Pierre
AU  - Gao,Qiang
AU  - Zhang,Bailin
AU  - Rak,Alexey
AU  - Hoffmann,Dietmar
AU  - Rooney,Eamonn
AU  - Vassort,Aurelie
AU  - Englaro,Walter
AU  - Li,Yi
AU  - Patel,Vinod
AU  - Adrian,Francisco
AU  - Gross,Stefan
AU  - Wiederschain,Dmitri
AU  - Cheng,Hong
AU  - Licht,Stuart
TI  - Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule
SN  - 1083-351X
PY  - 2015///0421
KW  - Allosteric Site
KW  - Crystallography, X-Ray
KW  - DNA Methylation
KW  - genetics
KW  - Drug Discovery
KW  - Enzyme Inhibitors
KW  - chemical synthesis
KW  - Escherichia coli
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - Isocitrate Dehydrogenase
KW  - antagonists & inhibitors
KW  - Magnesium
KW  - chemistry
KW  - Mutant Proteins
KW  - Neoplasms
KW  - drug therapy
KW  - Protein Conformation
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1074/jbc.M114.608497
ER  -