Deng, Gejing <br/><br/>
Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.  [electronic resource] 

 -  The Journal of biological chemistry  Jan 2015 
 - 762-74 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M114.608497  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Site<br/>Crystallography, X-Ray<br/>DNA Methylation--genetics<br/>Drug Discovery<br/>Enzyme Inhibitors--chemical synthesis<br/>Escherichia coli<br/>Gene Expression Regulation, Neoplastic<br/>Humans<br/>Isocitrate Dehydrogenase--antagonists & inhibitors<br/>Magnesium--chemistry<br/>Mutant Proteins--chemistry<br/>Neoplasms--drug therapy<br/>Protein Conformation