TY - GEN AU - Kashlan,Ossama B AU - Blobner,Brandon M AU - Zuzek,Zachary AU - Tolino,Michael AU - Kleyman,Thomas R TI - Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft SN - 1083-351X PY - 2015///0407 KW - Acid Sensing Ion Channels KW - chemistry KW - Action Potentials KW - Allosteric Regulation KW - Amiloride KW - Amino Acid Sequence KW - Animals KW - Binding Sites KW - Epithelial Sodium Channel Blockers KW - Epithelial Sodium Channels KW - Gene Expression KW - Ion Transport KW - Mice KW - Models, Molecular KW - Molecular Sequence Data KW - Mutation KW - Oocytes KW - Patch-Clamp Techniques KW - Protein Binding KW - Protein Structure, Secondary KW - Protein Structure, Tertiary KW - Protein Subunits KW - Sequence Alignment KW - Sodium KW - Xenopus laevis N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1074/jbc.M114.606152 ER -