TY  - GEN
AU  - Sharma,Raman
AU  - Litchfield,John
AU  - Bergman,Arthur
AU  - Atkinson,Karen
AU  - Kazierad,David
AU  - Gustavson,Stephanie M
AU  - Di,Li
AU  - Pfefferkorn,Jeffrey A
AU  - Kalgutkar,Amit S
TI  - Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment
SN  - 1521-009X
PY  - 2015///1124
KW  - Aged
KW  - Animals
KW  - Animals, Inbred Strains
KW  - Biotransformation
KW  - Carbon Radioisotopes
KW  - Dogs
KW  - Drug Evaluation, Preclinical
KW  - Enzyme Activators
KW  - analysis
KW  - Feces
KW  - chemistry
KW  - Female
KW  - Glucokinase
KW  - Half-Life
KW  - Humans
KW  - Hypoglycemic Agents
KW  - Imidazoles
KW  - Liver
KW  - drug effects
KW  - Male
KW  - Middle Aged
KW  - Molecular Structure
KW  - Nicotinic Acids
KW  - Organ Specificity
KW  - Rats, Sprague-Dawley
N1  - Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article
UR  - https://doi.org/10.1124/dmd.114.061218
ER  -