Sharma, Raman <br/><br/>
Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Feb 2015 
 - 190-8 p.  digital 
<br/><br/> Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.114.061218  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aged<br/>Animals<br/>Animals, Inbred Strains<br/>Biotransformation<br/>Carbon Radioisotopes<br/>Dogs<br/>Drug Evaluation, Preclinical<br/>Enzyme Activators--analysis<br/>Feces--chemistry<br/>Female<br/>Glucokinase--chemistry<br/>Half-Life<br/>Humans<br/>Hypoglycemic Agents--analysis<br/>Imidazoles--analysis<br/>Liver--drug effects<br/>Male<br/>Middle Aged<br/>Molecular Structure<br/>Nicotinic Acids--analysis<br/>Organ Specificity<br/>Rats, Sprague-Dawley