TY - GEN AU - Falchook,Gerald S AU - Wheler,Jennifer J AU - Naing,Aung AU - Jackson,Edward F AU - Janku,Filip AU - Hong,David AU - Ng,Chaan S AU - Tannir,Nizar M AU - Lawhorn,Kristie N AU - Huang,Mei AU - Angelo,Laura S AU - Vishwamitra,Deeksha AU - Hess,Kenneth AU - Howard,Adrienne N AU - Parkhurst,Kristin L AU - Amin,Hesham M AU - Kurzrock,Razelle TI - Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab SN - 1949-2553 PY - 2015///0730 KW - Adult KW - Aged KW - Antibodies, Monoclonal, Humanized KW - administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols KW - therapeutic use KW - Bevacizumab KW - Boronic Acids KW - Bortezomib KW - Breast Neoplasms KW - drug therapy KW - Carcinoma, Renal Cell KW - Fatigue KW - etiology KW - Female KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - antagonists & inhibitors KW - Kidney Neoplasms KW - Magnetic Resonance Imaging KW - Male KW - Middle Aged KW - Neoplasm Staging KW - Neovascularization, Pathologic KW - Proteasome Endopeptidase Complex KW - drug effects KW - Pyrazines KW - Thrombocytopenia KW - Treatment Outcome KW - Vascular Endothelial Growth Factor A KW - immunology KW - Vascular Endothelial Growth Factor Receptor-2 KW - metabolism N1 - Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.18632/oncotarget.2163 ER -