Gu, Mingxia

Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. [electronic resource] - European heart journal Apr 2015 - 806-16 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1522-9645

10.1093/eurheartj/ehu411 doi


Analysis of Variance
Animals
Apoptosis--physiology
Cell Differentiation
Diet, High-Fat
Endothelial Cells--physiology
Enzyme Inhibitors--pharmacology
Fibroblasts--physiology
Hindlimb--blood supply
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Induced Pluripotent Stem Cells--physiology
Injections, Intramuscular
Ischemia--physiopathology
Mice, Inbred C57BL
Muscle, Skeletal
Muscular Diseases--prevention & control
NG-Nitroarginine Methyl Ester--pharmacology
Nitric Oxide--physiology
Nitric Oxide Synthase Type III--metabolism
Obesity--physiopathology
Oxidative Stress--physiology
Pravastatin--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Random Allocation
Reperfusion Injury--physiopathology
Signal Transduction