TY  - GEN
AU  - Rahimi,Yasmeen
AU  - Camporez,João-Paulo G
AU  - Petersen,Max C
AU  - Pesta,Dominik
AU  - Perry,Rachel J
AU  - Jurczak,Michael J
AU  - Cline,Gary W
AU  - Shulman,Gerald I
TI  - Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance
SN  - 1091-6490
PY  - 2015///0423
KW  - Animals
KW  - Carnitine
KW  - analogs & derivatives
KW  - Citric Acid Cycle
KW  - Dietary Fats
KW  - pharmacology
KW  - Enzyme Activation
KW  - Fatty Acids
KW  - metabolism
KW  - Glucose
KW  - Glycogen
KW  - Hyperinsulinism
KW  - Insulin Resistance
KW  - physiology
KW  - Isoenzymes
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Models, Biological
KW  - Muscle, Skeletal
KW  - Nuclear Magnetic Resonance, Biomolecular
KW  - Oxidation-Reduction
KW  - Oxidative Stress
KW  - Phosphorylation
KW  - Protein Kinase C
KW  - Protein Kinase C-theta
KW  - Protein Processing, Post-Translational
KW  - Protein Serine-Threonine Kinases
KW  - deficiency
KW  - Pyruvate Dehydrogenase Acetyl-Transferring Kinase
KW  - Pyruvate Dehydrogenase Complex
KW  - genetics
KW  - RNA, Messenger
KW  - biosynthesis
KW  - Reactive Oxygen Species
KW  - Substrate Specificity
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1073/pnas.1419104111
ER  -