Zhang, Donghong <br/><br/>
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.  [electronic resource] 

 -  Arteriosclerosis, thrombosis, and vascular biology  Jan 2015 
 - 71-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1524-4636 
<br/><br/><label>Standard No.: </label>10.1161/ATVBAHA.114.303899  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Angiotensin II--metabolism<br/>Animals<br/>Binding Sites<br/>CCCTC-Binding Factor<br/>Cells, Cultured<br/>Cellular Senescence--drug effects<br/>Cyclin-Dependent Kinase Inhibitor p16--metabolism<br/>Cyclin-Dependent Kinase Inhibitor p21--metabolism<br/>DNA Methylation--drug effects<br/>Disease Models, Animal<br/>Folic Acid--pharmacology<br/>Gene Expression Regulation, Enzymologic<br/>Homocysteine--pharmacology<br/>Human Umbilical Vein Endothelial Cells--drug effects<br/>Humans<br/>Hyperhomocysteinemia--blood<br/>Male<br/>Mice, Inbred C57BL<br/>Promoter Regions, Genetic<br/>RNA Interference<br/>Repressor Proteins--genetics<br/>S-Adenosylmethionine--pharmacology<br/>Sp1 Transcription Factor--genetics<br/>Telomerase--genetics<br/>Telomere--drug effects<br/>Telomere Shortening--drug effects<br/>Time Factors<br/>Transfection<br/>Tumor Suppressor Protein p53--metabolism