TY  - GEN
AU  - Nivarthi,Usha K
AU  - Gras,Stephanie
AU  - Kjer-Nielsen,Lars
AU  - Berry,Richard
AU  - Lucet,Isabelle S
AU  - Miles,John J
AU  - Tracy,Samantha L
AU  - Purcell,Anthony W
AU  - Bowden,David S
AU  - Hellard,Margaret
AU  - Rossjohn,Jamie
AU  - McCluskey,James
AU  - Bharadwaj,Mandvi
TI  - An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant
SN  - 1550-6606
PY  - 2015///0416
KW  - Antigenic Variation
KW  - genetics
KW  - CD8-Positive T-Lymphocytes
KW  - immunology
KW  - Cells, Cultured
KW  - Crystallography, X-Ray
KW  - Cytotoxicity, Immunologic
KW  - Epitopes, T-Lymphocyte
KW  - HLA-B8 Antigen
KW  - metabolism
KW  - Hepacivirus
KW  - Hepatitis C
KW  - Humans
KW  - Immunodominant Epitopes
KW  - Mutation
KW  - Peptide Fragments
KW  - Protein Binding
KW  - Protein Conformation
KW  - Protein Engineering
KW  - Protein Stability
KW  - Receptors, Antigen, T-Cell
KW  - Structure-Activity Relationship
KW  - Viral Nonstructural Proteins
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.4049/jimmunol.1401357
ER  -