TY  - GEN
AU  - Knight,E M
AU  - Williams,H N
AU  - Stevens,A C
AU  - Kim,S H
AU  - Kottwitz,J C
AU  - Morant,A D
AU  - Steele,J W
AU  - Klein,W L
AU  - Yanagisawa,K
AU  - Boyd,R E
AU  - Lockhart,D J
AU  - Sjoberg,E R
AU  - Ehrlich,M E
AU  - Wustman,B A
AU  - Gandy,S
TI  - Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ
SN  - 1476-5578
PY  - 2015///0330
KW  - Alzheimer Disease
KW  - complications
KW  - Amyloid beta-Peptides
KW  - metabolism
KW  - Amyloid beta-Protein Precursor
KW  - genetics
KW  - Animals
KW  - Antipsychotic Agents
KW  - therapeutic use
KW  - Blood-Testis Barrier
KW  - drug effects
KW  - Cells, Cultured
KW  - Cognition Disorders
KW  - drug therapy
KW  - Disease Models, Animal
KW  - Dose-Response Relationship, Drug
KW  - Fibroblasts
KW  - Gangliosides
KW  - Humans
KW  - Maze Learning
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mutation
KW  - Recognition, Psychology
KW  - Time Factors
KW  - beta-N-Acetylhexosaminidases
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/mp.2014.135
ER  -