TY - GEN AU - Fang,Nancy N AU - Chan,Gerard T AU - Zhu,Mang AU - Comyn,Sophie A AU - Persaud,Avinash AU - Deshaies,Raymond J AU - Rotin,Daniela AU - Gsponer,Joerg AU - Mayor,Thibault TI - Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress SN - 1476-4679 PY - 2015///0310 KW - Animals KW - Cell Line, Tumor KW - Crystallography, X-Ray KW - Endosomal Sorting Complexes Required for Transport KW - genetics KW - HSP40 Heat-Shock Proteins KW - metabolism KW - HeLa Cells KW - Heat-Shock Response KW - physiology KW - Hot Temperature KW - Humans KW - Mice KW - Nedd4 Ubiquitin Protein Ligases KW - Peptide Termination Factors KW - Protein Folding KW - Protein Structure, Tertiary KW - Pyruvate Decarboxylase KW - Pyruvate Kinase KW - Saccharomyces cerevisiae KW - enzymology KW - Saccharomyces cerevisiae Proteins KW - Ubiquitin KW - Ubiquitin-Protein Ligase Complexes KW - Ubiquitin-Protein Ligases KW - Ubiquitination N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/ncb3054 ER -