TY - GEN AU - Hoffner,Guylaine AU - Djian,Philippe TI - Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity? SN - 1559-1182 PY - 2016///0808 KW - Amyloid KW - chemistry KW - Animals KW - Animals, Genetically Modified KW - Birefringence KW - Brain KW - ultrastructure KW - Epitopes KW - Humans KW - Huntingtin Protein KW - Huntington Disease KW - metabolism KW - Inclusion Bodies KW - Mice KW - Models, Molecular KW - Nerve Tissue Proteins KW - Peptide Fragments KW - Peptide Hydrolases KW - Peptides KW - immunology KW - Polymerization KW - Protein Aggregates KW - physiology KW - Protein Aggregation, Pathological KW - Protein Folding KW - Protein Structure, Secondary KW - Protein Transport KW - Rats KW - Solubility KW - Structure-Activity Relationship KW - X-Ray Diffraction N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review UR - https://doi.org/10.1007/s12035-014-8932-1 ER -