A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. [electronic resource]
- Nature chemical biology Dec 2014
- 1013-9 p. digital
Publication Type: Journal Article
1552-4469
10.1038/nchembio.1681 doi
Adenosine Triphosphate--chemistry Antineoplastic Agents--chemical synthesis Autophagy--drug effects Catalytic Domain Cell Line, Tumor Cell Proliferation--drug effects Class III Phosphatidylinositol 3-Kinases--antagonists & inhibitors Drug Synergism Endosomes--drug effects Everolimus Gene Expression Humans Kidney--enzymology Kinetics Lysosomes--drug effects Molecular Docking Simulation Protein Kinase Inhibitors--chemical synthesis Pyridines--chemical synthesis Pyrimidinones--chemical synthesis Recombinant Proteins--chemistry Signal Transduction Sirolimus--analogs & derivatives TOR Serine-Threonine Kinases--antagonists & inhibitors