Liu, Yubo <br/><br/>
A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.  [electronic resource] 

 -  Pigment cell & melanoma research  Mar 2015 
 - 161-70 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1755-148X 
<br/><br/><label>Standard No.: </label>10.1111/pcmr.12325  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins--metabolism<br/>Bcl-2-Like Protein 11<br/>Caspases--metabolism<br/>Cell Line, Tumor<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>Gossypol--pharmacology<br/>Humans<br/>JNK Mitogen-Activated Protein Kinases--metabolism<br/>Melanoma--pathology<br/>Membrane Proteins--metabolism<br/>Mice<br/>Mitochondria--drug effects<br/>Myeloid Cell Leukemia Sequence 1 Protein--metabolism<br/>Phosphorylation--drug effects<br/>Proteolysis--drug effects<br/>Proto-Oncogene Proteins--metabolism<br/>Proto-Oncogene Proteins c-bcl-2--metabolism<br/>Signal Transduction--drug effects<br/>Substrate Specificity--drug effects<br/>bcl-2 Homologous Antagonist-Killer Protein--metabolism