TY  - GEN
AU  - Sandhöfer,N
AU  - Metzeler,K H
AU  - Rothenberg,M
AU  - Herold,T
AU  - Tiedt,S
AU  - Groiß,V
AU  - Carlet,M
AU  - Walter,G
AU  - Hinrichsen,T
AU  - Wachter,O
AU  - Grunert,M
AU  - Schneider,S
AU  - Subklewe,M
AU  - Dufour,A
AU  - Fröhling,S
AU  - Klein,H-G
AU  - Hiddemann,W
AU  - Jeremias,I
AU  - Spiekermann,K
TI  - Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia
SN  - 1476-5551
PY  - 2015///0604
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Drug Synergism
KW  - Gene Expression Regulation, Leukemic
KW  - Gene Rearrangement
KW  - Heterocyclic Compounds, 3-Ring
KW  - Humans
KW  - Imidazoles
KW  - Leukemia, Myeloid, Acute
KW  - drug therapy
KW  - Mice
KW  - Myeloid-Lymphoid Leukemia Protein
KW  - genetics
KW  - Oncogene Proteins, Fusion
KW  - Phosphatidylinositol 3-Kinases
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-akt
KW  - antagonists & inhibitors
KW  - Quinolines
KW  - Signal Transduction
KW  - Sirolimus
KW  - Survival Analysis
KW  - TOR Serine-Threonine Kinases
KW  - Tumor Burden
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/leu.2014.305
ER  -