TY  - GEN
AU  - Zou,Taisong
AU  - Risso,Valeria A
AU  - Gavira,Jose A
AU  - Sanchez-Ruiz,Jose M
AU  - Ozkan,S Banu
TI  - Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme
SN  - 1537-1719
PY  - 2015///0818
KW  - Anti-Bacterial Agents
KW  - metabolism
KW  - Bacteria
KW  - enzymology
KW  - Catalytic Domain
KW  - Evolution, Molecular
KW  - Molecular Dynamics Simulation
KW  - Mutation
KW  - Principal Component Analysis
KW  - Protein Structure, Tertiary
KW  - Substrate Specificity
KW  - beta-Lactamases
KW  - chemistry
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1093/molbev/msu281
ER  -