A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. [electronic resource]
- Nature chemical biology Dec 2014
- 1055-60 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1552-4469
10.1038/nchembio.1669 doi
Animals Brain--drug effects Cell Line Coculture Techniques Gene Expression HMGB1 Protein--genetics HMGB2 Protein--genetics Heterocyclic Compounds, 4 or More Rings--pharmacology Inflammation--chemically induced Lipopolysaccharides Male Mice Mice, Inbred C57BL Microglia--drug effects Neuroimmunomodulation Neurons--drug effects Neuroprotective Agents--pharmacology Protein Binding Protein Processing, Post-Translational Tumor Necrosis Factor-alpha--biosynthesis