Lee, Sanghee

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. [electronic resource] - Nature chemical biology Dec 2014 - 1055-60 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1552-4469

10.1038/nchembio.1669 doi


Animals
Brain--drug effects
Cell Line
Coculture Techniques
Gene Expression
HMGB1 Protein--genetics
HMGB2 Protein--genetics
Heterocyclic Compounds, 4 or More Rings--pharmacology
Inflammation--chemically induced
Lipopolysaccharides
Male
Mice
Mice, Inbred C57BL
Microglia--drug effects
Neuroimmunomodulation
Neurons--drug effects
Neuroprotective Agents--pharmacology
Protein Binding
Protein Processing, Post-Translational
Tumor Necrosis Factor-alpha--biosynthesis