TY  - GEN
AU  - Talbert,Dominique R
AU  - Doherty,Kimberly R
AU  - Trusk,Patricia B
AU  - Moran,Diarmuid M
AU  - Shell,Scott A
AU  - Bacus,Sarah
TI  - A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity
SN  - 1096-0929
PY  - 2016///0105
KW  - Actin Cytoskeleton
KW  - drug effects
KW  - Antineoplastic Agents
KW  - toxicity
KW  - Cell Death
KW  - Cell Differentiation
KW  - Cell Line
KW  - Dose-Response Relationship, Drug
KW  - Heart Diseases
KW  - chemically induced
KW  - Heart Rate
KW  - Humans
KW  - Imidazoles
KW  - Induced Pluripotent Stem Cells
KW  - Mitochondria, Heart
KW  - Myocytes, Cardiac
KW  - Oxidative Stress
KW  - Protein Kinase Inhibitors
KW  - Pyridazines
KW  - Risk Assessment
KW  - Signal Transduction
KW  - Time Factors
KW  - Toxicity Tests
KW  - methods
KW  - Troponin
KW  - metabolism
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1093/toxsci/kfu215
ER  -