Talbert, Dominique R <br/><br/>
A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity.  [electronic resource] 

 -  Toxicological sciences : an official journal of the Society of Toxicology  Jan 2015 
 - 147-55 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1096-0929 
<br/><br/><label>Standard No.: </label>10.1093/toxsci/kfu215  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Actin Cytoskeleton--drug effects<br/>Antineoplastic Agents--toxicity<br/>Cell Death--drug effects<br/>Cell Differentiation<br/>Cell Line<br/>Dose-Response Relationship, Drug<br/>Heart Diseases--chemically induced<br/>Heart Rate--drug effects<br/>Humans<br/>Imidazoles--toxicity<br/>Induced Pluripotent Stem Cells--drug effects<br/>Mitochondria, Heart--drug effects<br/>Myocytes, Cardiac--drug effects<br/>Oxidative Stress--drug effects<br/>Protein Kinase Inhibitors--toxicity<br/>Pyridazines--toxicity<br/>Risk Assessment<br/>Signal Transduction--drug effects<br/>Time Factors<br/>Toxicity Tests--methods<br/>Troponin--metabolism