TY - GEN AU - Muir,Alexander AU - Ramachandran,Subramaniam AU - Roelants,Françoise M AU - Timmons,Garrett AU - Thorner,Jeremy TI - TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids SN - 2050-084X PY - 2016///0411 KW - Autophagy KW - Calcineurin KW - metabolism KW - Cell Survival KW - Down-Regulation KW - Glycogen Synthase Kinase 3 KW - Heat-Shock Response KW - Mechanistic Target of Rapamycin Complex 2 KW - Membrane Proteins KW - Models, Biological KW - Multiprotein Complexes KW - Oxidoreductases KW - Phosphorylation KW - Phosphoserine KW - Saccharomyces cerevisiae KW - cytology KW - Saccharomyces cerevisiae Proteins KW - Signal Transduction KW - Sphingolipids KW - biosynthesis KW - Stress, Physiological KW - Substrate Specificity KW - TOR Serine-Threonine Kinases KW - Up-Regulation N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.7554/eLife.03779 ER -