TY - GEN AU - von Minckwitz,Gunter AU - Puglisi,Fabio AU - Cortes,Javier AU - Vrdoljak,Eduard AU - Marschner,Norbert AU - Zielinski,Christoph AU - Villanueva,Cristian AU - Romieu,Gilles AU - Lang,István AU - Ciruelos,Eva AU - De Laurentiis,Michele AU - Veyret,Corinne AU - de Ducla,Sabine AU - Freudensprung,Ulrich AU - Srock,Stefanie AU - Gligorov,Joseph TI - Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): an open-label, randomised phase 3 trial SN - 1474-5488 PY - 2015///0127 KW - Adult KW - Aged KW - Antibodies, Monoclonal, Humanized KW - administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols KW - Bevacizumab KW - Breast Neoplasms KW - drug therapy KW - Disease-Free Survival KW - Dose-Response Relationship, Drug KW - Drug Administration Schedule KW - Follow-Up Studies KW - Genes, erbB-2 KW - genetics KW - Humans KW - Maximum Tolerated Dose KW - Middle Aged KW - Neoplasm Invasiveness KW - pathology KW - Neoplasm Recurrence, Local KW - Neoplasm Staging KW - Patient Selection KW - Remission Induction KW - methods KW - Retreatment KW - Survival Analysis KW - Time Factors KW - Treatment Outcome N1 - Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/S1470-2045(14)70439-5 ER -